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phosphoridine chloride

2021-09-02 10:24:35   Click:

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[Name] phosphoridine chloride
 
[CAS NO] 51-15-0
 
[Properties] This product is white crystalline powder. This product is soluble in water.
 
[pharmacological action] the strain oxime compounds, the quaternary ammonium groups can tend to combine with organophosphorus pesticides has lost vitality of phosphorus acylation of cholinesterase cation site, its nucleophilic groups can be directly combined with cholinesterase phosphorylation groups and then together out of cholinesterase, cholinesterase returned to square one, to show vitality, The activation of "aged" cholinesterase inhibited by organophosphorus insecticides for more than 36 hours was very poor. It did not revive cholinesterase inhibited by chronic organic phosphorus pesticide poisoning. 12.. It has obvious effects on nicotinoid symptoms caused by organophosphorus insecticides, and weak as follows: it has unknown effects on central nervous system symptoms. The content of crotch of this product was 79.5%, while that of phosphodesidine iodide was only 51.9%. Therefore, the efficacy of 1g of this product is equivalent to 1.5g of phosphodesidine iodide. Water soluble (640mg/ml,25℃), good stability, complete local absorption, for intramuscular injection. 43 cases of organophosphorus pesticide poisoning were reported. The average activity of blood cholinesterase was about 50% of normal value. After intramuscular injection of 0.5 ~ 1g, the symptoms of clinical poisoning mostly disappeared within 30 minutes ~ 1 hour, and the activity of blood cholinesterase recovered to more than 70% of the normal value.
 
[Application] It can revive the cholinesterase activity inhibited by acute organophosphorus insecticides to different degrees, and is used to rescue the poisoning of various organophosphorus ester insecticides. However, the toxicity effect of malathion, trichlorfon, dichlorvos, dimethoate, meflon, propylamine fluophos and octadecphos was poor. It did not revive the cholinesterase inhibited by carbamate insecticide.
 
[Usage and Dosage] 1. Mild poisoning: intramuscular injection of 0.25 ~ 0.5 g, 2 hours later if necessary, repeat 1 time. 2. Moderate poisoning: intramuscular injection of 0.5 ~ 0.75 g. 3. Severe poisoning: intravenous injection of 1g.

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